The history tells us that the mind altering substances have been the interest of people since the dawn of time. Some of these drugs are widely known as life-changing drugs and majority of people in the world today probably have had experiences with any of such drugs, including prescription pills alcohol etc. below list describes most notorious drugs and their side effects.You will be amazed reading this name in this list, but in fact prescription drugs are getting popularity more than your imagination. The usage of these drugs has increased rapidly since the past decade. Some of the prescription drugs, including OxyContin and Vicodin, are really on top and are known as the most abused prescription drugs used by majority of people. It’s believed that prescription drugs may produce side effects similar to the effects we see in heroin cases.This is the second drug in this list of most notorious drugs and their side effects that relates to cocaine which is generally recognized with its nickname “crack cocaine”. Some believe crack cocaine earned fame sometime during 1980s. Typically, this drug is not produced by processing through any kind of filtration process and thus is really dangerous to health. It is made by cooking it with baking soda (though initially it was baked with ammonia).Marijuana is among those drugs in our list that are rapidly earning fame in the people who want to live their lives in drugs. This sixth top-rated notorious drug is also categorized as the most abused illicit drug in United States. It is extracted from the Cannabis plant’s dried parts. Marijuana can adversely affects memory, and can cause learning problem in addition to causing the impaired coordination effects in its users.Methamphetamime is the fifth notorious drug in our list that has many side effects, but still is widely used by its lovers who also call this drug with different names including ice or meth. It’s a kind of sympathomimetic as well as psychostimulant drug. It directly affects brain where it may trigger serotonin, dopamine and norepinephrine’s cascading releases. It may also cause in producing excitement and euphoria.Tobacco products are also very popular drugs that are widely and commonly used by tens of millions on daily basis because tobacco is a legal drug in almost every nation. Nearly 69.9 million people are tobacco addict only in United States. Smoking turns on natural chemicals of the body and provides pleasure centers in brain that produces euphoria in users. This drug is famous for causing long-term effects, including high risk of cancer and blood pressure.Cocaine is a kind of drug which is obtained / created from coca plant as this crystalline tropane alkaloid comes from this plant’s leaves. This 3rd in most notorious drugs and their side effects list drug directly affects central nervous system of the user, and may also result in causing a sense of increased energy or happiness. Most of its users use Cocaine to get increased energy effect and this effect may last within its users somewhere between 20 minutes to many hours.The latest survey reports in United States claimed that more than half of this super power’s population has been identified as drinkers (alcohol addict). Therefore, you may put it at No. 1 place as the most abused substance in United States. 6.7% of these drinkers are categorized as heavy drinkers. This second top-rated drug is famous for producing several notorious effects including slurred speech, impaired judgment and coordination, and black-outs.Heroin is probably the most notorious and widely used drug at the moment across the globe regardless of region and race discrimination. It is the drug which is directly extracted from the opium poppy. Originally this drug was created with an intention to help cure those people who were losing their lives of morphine addiction. Heroin eventually develops a sense of well-being and gets converted into morphine in users. It’s generally used through intravenous injection.